( 1. Letrozole tersedia dalam bentuk tablet (tablet-coated film) yang tersedia dengan sediaan 2. . While the rates of clinical or biochemical pregnancy and implantation were similar between the groups, the miscarriage rate was significantly lower in the letrozole group (9. and R$3. sudden loss of coordination. 5’ on other side. The purpose of this paper is to. Letrozole has been used with increasing frequency in infertility therapy. Use of letrozole may cause decreases in bone mineral density (BMD). It is also used to help prevent cancer recurrence. 35 for placebo and letrozole, respectively; P = . Methods: Adult heights and long-term follow-up data, including. Oestrogen stimulates some breast cancers to grow. SettingTertiary care academic medical center. 5. massage. Due to the promising preclinical and phase 1 results, and once again to shorten development. It is used in postmenopausal women for the adjuvant treatment of early breast cancer, for extended adjuvant therapy after 5 years of tamoxifen, and for the treatment of advanced breast cancer. Lez is used for Breast cancer, Infertility due to anovulation. The cumulative ovulation rate was higher with letrozole than with clomiphene (834 of 1352 treatment cycles [61. PopulationA total of 6,874 infertile women with regular. 24, 95% CI 1. It is used as the second treatment. 1. and R$50 - R$300 in Brazil. Background Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes following stimulated. Letrozole reduces the amount of estrogen by blocking an enzyme (“aromatase. Showing the single result Lez-T Letrozole 2. Background. Recent studies have shown that letrozole can be used effectively for ovulation induction. In this video i am telling about lezra tablet. Letrozole decreases the amount of estrogen. Care and support Pregnancy NHS services Most people who take letrozole will have had surgery, radiotherapy or sometimes chemotherapy to treat their breast cancer first. This activity describes the indications, action, and contraindications for anastrozole as a valuable agent in managing advanced hormone-receptive breast cancer. Like all medications, letrozole can cause side effects. Letrozole Teva contains an active substance called letrozole. Many cancers are hormone sensitive (estrogen or progesterone receptor positive) and their growth can be affected by lowering estrogen levels in the body. Letrozole tablets may cause fetal harm when administered to a pregnant woman and the clinicl benefit to premenopausal women with breast cancer has not been demonstrated. Levalbuterol comes as a solution (liquid) to inhale by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled), a concentrated solution to be mixed with normal saline and inhaled by mouth using a nebulizer, and as an aerosol to inhale by mouth using an inhaler. 688 of 1425 treatment cycles [48. Always take letrozole exactly as your doctor has told you. (2018). What is letrozole used for? Letrozole is used to treat breast cancer in women after menopause (change of life). The use of misoprostol to induce labor is contraindicated in many international guidelines because the risk of uterine rupture was found to increase by up to 18% in one study, even when a very low dose of 25 µg was administered 7. 0) Other: 5 (3. 5 mg Film-coated tablets should only be used in women with a clearly established postmenopausal status (see section 4. Learn about side effects, warnings, dosage, and more. You usually take letrozole once a day – try. Letrozole blocks the synthesis of estrogen in ovarian granulosa cells, resulting in reduced levels of circulating and intraovarian estrogens and increased levels of intraovarian androgens (Velasco and. Letrozole is used to treat breast cancer in postmenopausal women. Letrozole Accord contains an active substance called letrozole. Consideration should be given to monitoring BMD. It reduces the amount of estrogen produced by the body. Letrozole may also be used for purposes not listed in this medication guide. vaginal bleeding. Arimidex is sometimes taken to lower estrogen levels that are high due to anabolic steroid use. We cover the options for lesbian women doing artificial insemination, either at home, or an IUI intrauterine insemination through a doctor, including the choice of whether to use medications like clomid, letrozole, or gonadotropins. Clomid stimulates the release of hormones. An RE could monitor you pre/post ovulation to check your follicles, hormones, etc to see if everything is working correctly. 4 months of letrozole 2. Introduction In vitro fertilisation (IVF) is an effective infertility treatment but the live birth rate remains unsatisfactory. 5. 5 milligrams (mg) 2. Letrozole-induced cycles had improved clinical pregnancy and live birth rates after FETs, compared to artificial and gonadotropin-based ovarian stimulation cycles [14–16]. Anastrozole competitively inhibits the aromatase enzyme, which synthesizes estrogen [1, 2]. Background Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990. Letrozole is a generic drug also sold under the brand name Femara. 007). 29 A recent Cochrane review, by Franik et al, based on moderate-quality evidence, found higher live birth rates with letrozole compared to CC, and based on high-quality evidence, also. If you experience either or both of these side effects, you should not drive, use machinery, or perform any other activities that require alertness. Contemporary studies that have directly examined the use of letrozole for endometrial preparation have similarly demonstrated that, among other effects of letrozole on the endometrium, letrozole-induced reduction in follicular phase E2 serum levels may improve endometrial receptivity and embryo implantation (23, 33, 36). Femara is a brand (trade) name for letrozole. 5 mg Tablets ₨ 6,000 Add to cart. It is a hormonal (or “endocrine”) treatment for breast cancer. Clomid and Letrozole have emerged as go-to options for individuals seeking effective PCT strategies. Togas Tulandi at McGill University to propose a multicenter Canadian study designed to compare birth outcomes in women conceiving after the use of CC or letrozole. Most importantly, a preliminary study focused on PCOS patients demonstrated that letrozole use for ovulation induction increased a number of markers of endometrial receptivity, which might have a positive effect on embryo implantation (7). increased cholesterol in your blood. Those receiving letrozole had a significantly greater decrease in total hip BMD (percentage change in T score, mean −0. 5 mg 30’s. Bahan-bahan lain yang terkandung di dalamnya adalah laktosa monohidrat, selulosa mikrokristalin (E460), pati jagung yang dipragelatinisasi, natrium pati glikolat, magnesium stearat (E572), silikon dioksida koloid (E551). Letrozole is also used to induce ovulation in women who exhibit polycystic ovary syndrome or anovulation. Common Femara side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or. This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Yellow skin and yellow whites of the eyes, nausea, decreased appetite, dark urine (signs of hepatitis ). Not able to sleep. 5. “Any time” includes follow-up period after completion or discontinuation of study treatment. 5mg Tablet belongs to the therapeutic classification of Cytotoxic Chemotherapy Drugs. Drug Images What is letrozole? If you have a certain type of breast cancer, your doctor may prescribe letrozole oral tablets for you. . The most frequently reported adverse reactions were bone pain, hot flushes, back pain, nausea, arthralgia and dyspnea. Some complementary and holistic medicine techniques have been shown to ease bone pain, including: acupuncture. So, your ovaries produce more. 1 The Study of Letrozole Extension (SOLE) study compared intermittent (3. Side effects usually improve after a few months as your body gets used to the medicine. Dosing: Adult. If a woman does have a regular cycle, she can start medications on either day 3 or day 5 following the start of bleeding. Some side effects are very common (may affect more than 1 user in 10): Hemorrhoids. 1. 0) Unexplained: 34 (21. increased cholesterol levels. Clomid or letrozole have 4 - 9% live birth rates, 1 - 13% of pregnancies result in multiples, and costs can be as low as $500 in the U. itchiness. This product is available in the following dosage forms: Tablet; Before Using. , during the weekend, or on a holiday, call 212-639-2000. letrozole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. PATIENTS AND METHODS: Nine hundred seven patients were randomly assigned letrozole 2. As there are reports of women regaining ovarian function during treatment with letrozole despite a clear postmenopausal status at start of therapy, the physician needs to discuss adequate contraception when. Letrozole के लाभ और उपयोग करने का तरीका - Letrozole Benefits & Uses in Hindi Letrozole इन बिमारियों के इलाज में काम आती है - Use of letrozole in CDGP was associated with a slower progression in BA when compared to those receiving placebo or testosterone. sudden, severe weakness or numbness in the arm or leg. 5mg letrozole for improving fertility. Nausea. It sounds like your OB isn’t monitoring you. In postmenopausal women with hormone receptor-positive breast cancer, extended use of intermittent letrozole did not improve disease-free survival compared with continuous use of letrozole. Letrozole works by decreasing the amounts of these hormones in the body. It can also be used in premenopausal women having ovarian suppression. It’s produced mainly by adrenal glands as well as the testicles. This type of breast cancer is called oestrogen receptor-positive breast. 5mg letrozole for improving fertility. It is available on prescription only. It can also cause more fatigue (lack of energy). Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Femara (letrozole) is a brand-name prescription drug used for certain types of breast cancer. For context, compared with IVF, IUI. In post-marketing reports, use of letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects. Early-stage breast cancer that has been treated with tamoxifen citrate for at least 5 years. swollen glands. This medicine is available only with your doctor's prescription. . to treat breast cancer in men and younger women. It works by decreasing the amount of estrogen produced by the body. to treat breast cancer in men and younger women. Letrozole is a medication that treats breast cancer and infertility. 33) and natural cycle (OR 1. It only works in women who are post-menopausal and producing estrogen outside the ovaries. Composition: Lezra excel contains 2. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a. So, ask an expert whether IUI is your ideal solution to conceive. Based on our results, it is advisable to evaluate serum lipid levels every 3 months during the initial 6 months of AI treatment, and thereafter after. joint pain *. , 2003). An alternative schedule of extended adjuvant endocrine therapy with letrozole, including intermittent administration, might be feasible and the. As there are reports of women regaining ovarian function during treatment with letrozole despite a clear postmenopausal status at start of therapy, the physician needs to discuss adequate contraception when. Some breast cancers are made to grow faster by a natural hormone called estrogen. 0 tablets) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 1mg. 5. The text only version may be available in large print, Braille or audio CD . 2) First and second-line treatment of. However, one side effect that can be particularly uncomfortable is gas and bloating. If you eat sweets or a high. 1. In the last few years, many studies have been published describing favourable results with use of letrozole in reproductive technologies with no short or long-term side effects [11–13]. 5 mg tablet administered once a day, regardless to meals. 1 Bone Effects. Clomid vs. Aromasin is a brand-name prescription medication. Letrozole Uses . But this combination can potentially cause rare adverse effects in the body, including kidney toxicity [95]. Do not drive or operate machinery until you know how the medication affects you. Some forms of cancer cells of breast that require estrogen to proliferate can be slowed or stopped by this. They’re commonly prescribed for people with polycystic ovary syndrome (PCOS) or unexplained infertility. Letrozole uses. Find everything you need to know about Letrozole (Femara), including what it is used for, warnings, reviews, side effects, and interactions. You should only take Lez-T if you have gone through menopause. 1. 5 mg tablet administered once a day, regardless to meals. IUI, or intrauterine insemination, is a relatively simple fertility treatment. Weight gain or loss. Approximately 12–18% of couples in the United States struggle with infertility, with 20% of infertility caused solely by male factors and 30–40% of infertility caused by a combination of male and female factors [1, 2]. 3%], P<0. Besides, no obvious discomforts were found in group B patients during pre-HIFU medication, and three of group C patients (27. 5 mg daily. Two studies, however, also used letrozole relatively close to the embryo transfer timing in fresh cycles with no reported adverse effects. Novartis, the company responsible for the production of Femara (letrozole) does not recommend the use of this drug as an inducer of ovulation. Letrozole comes in 2. It is a hormonal (or “endocrine”) treatment for breast cancer. If you have questions about side effects, call your doctor. The Novartis warning prompted Dr. ObjectiveWe describe the clinical characteristics and long-term treatment with letrozole on adult height of a boy diagnosed. 5 mg once daily. LH levels were measured in week 5 before pellet removal (Pre) and in week 11 (Post). 5 mg tablets: yellow round, biconvex, film coated tablets imprinted with 'LT' on one side and plain on other side. e. The growth of breast tumors is often stimulated by the female sex hormone estrogen . swollen glands. Belly pain. Letrozole Bluefish contains an active substance called letrozole. Background: The co-administration of letrozole during controlled ovarian stimulation (COS) with gonadotropins is used to limit the potentially harmful effects of a supra-physiological rise in estrogen levels on hormone-sensitive cancers. 1) Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant tamoxifen therapy. Letrozole is a nonsteroidal compound that inhibits estrogen production by blocking the enzyme aromatase. 1% taking tamoxifen; this was highly significant . It. 1. hair loss*. 60 for placebo and letrozole, respectively; P = . 32% of reviewers reported a positive experience, while 34% reported a negative experience. What are the side effects to using letrozole? The use of letrozole is associated with many side effects, including an increase in cholesterol levels, a decrease in bone density, hot flashes, night sweats, nausea and vomiting, loss of appetite, constipation, diarrhea and heartburn, muscle and joint pain, fatigue and dizziness, swelling of. 4. PCOS causes metabolic problems and hormonal imbalances that affect fertility. View uses, side effects, price in Pakistan and get expert advice. I have PCOS and don’t ovulate on my own, so had to take 10 days of progesterone to even get a period, then 2. My follicles showed zero progress at 12mm so doc had me up my dosage to 5mg of Letrozole (thankfully without having to re-start my cycle). You may report side effects to the FDA at 1-800-332-1088. Letrozole inhibits the production of Estrogen and thus prevents the growth of a Tumor. This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Use of letrozole may cause decreases in bone mineral density (BMD). Zhang J, Liu H, Wang Y, et al. If you have questions about side effects, call your doctor. For vaginal complaints such as dyspareunia, dryness and sexual dysfunction, topical estrogen may be considered. Femara (letrozole) is indicated for the adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. letrozole, severely impaired hepatic function, uncontrolled hypertension and thromboembolism. Treatment should be discontinued at tumor relapse. The growth of breast tumors is often stimulated by the female sex hormone estrogen . 2 Extended Adjuvant Treatment of Early Breast Cancer Femara is indicated for the extended adjuvant treatment of early breast cancer in postmenopausal women, who have received 5 years of adjuvant tamoxifen. dizziness or lightheadedness. For oral dosage form (tablets): For breast cancer: Adults—2. By decreasing the amount of estrogen in the body, letrozole can slow or stop. In patients with advanced disease, treatment with Letrozole Tablet should be continued until tumor progression is evident. 1 Bone Effects. 5 MG Tablet (10) online & get Flat 15% OFF on PharmEasy. It is also used to treat early breast cancer in women who have experienced menopause and who have. In both groups, if the women developed eggs and ovulated, then they had an IUI performed. Lez-T Letrozole 2. Letrozole Teva reduces the amount of estrogen by blocking an enzyme ("aromatase") that participates in the production of. Neoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG) Acta Oncologica: Vol. 2 Extended Adjuvant Treatment of Early Breast Cancer. Nice, France, March 21–25 (2006) (Abstract 12). ; The recommended dose of letrozole tablets is one 2. 5mg Tablet 10's and avail upto 20% discount. The use of letrozole has recently attracted attention as an effective alternative to natural or HRT cycles in patients with ovulation disorders undergoing FET (Huang et al. S. 5 mg, taken cycle days 3-7). At surgery, 23 (46·9%; 95% CI 32·5-61·7) of 49 patients in the ribociclib plus letrozole group and 24 (46·1%; 32·9-61·5) of 52 patients in the chemotherapy group were low-ROR. Letrozole suppresses plasma estradiol more completely than anastrozole . Consideration should be given to monitoring BMD. 1 Bone Effects. comLetrozole is a medication used in the treatment of certain breast cancers. Femara (letrozole) is a brand-name prescription drug used for certain types of breast cancer. slurred speech. Introduction. (AJOG, 2021) assessed the impact of letrozole (an aromatase inhibitor) during frozen embryo transfer (FET) on obstetrical and perinatal outcomes of singleton and twin pregnancies compared with artificial cycle FET among women with polycystic ovary syndrome METHODS: Retrospective. Discontinuations for adverse reactions other than progression of tumor occurred in 10/455 (2%) of patients on Femara and in 15/455 (3%) of patients on tamoxifen. nausea. Letrozole blocks the conversion of C-19 androgens to C-18 estrogens by competitively inhibiting the enzyme, aromatase (cytochrome P-450 19), which is an essential step in estrogen biosynthesis in the ovary and other tissues. It is a hormonal (or “endocrine”) treatment for breast cancer. Letrozole is used to treat breast cancer in women who have gone through menopause. The right time to start taking letrozole is on the third or fourth day of your menstrual cycle. Increased hepatic enzymes, hyperbilirubinemia, jaundice. However, few studies have investigated the clinical outcomes of letrozole in FET ( Hu et al . It may also be used off-label for fertility issues. Letrozole Teva reduces the amount of estrogen by blocking an. Letrozole is also used to help prevent the cancer. Letrozole dosage. In the extended adjuvant setting, the optimal treatment duration with letrozole tablets is not known. In fact, with Clomid, having more than six cycles is discouraged (a max of three to four is recommended). According to the most recent research, letrozole can be used as the first-line therapy to treat infertility caused by polycystic ovarian syndrome and other causes. The planned duLetrozole tablets USP, 2. Letrozole comes as tablets. Day 17 (Lønning et al. Serum total testosterone was measured in placebo and letrozole-treated mice in week 13 (Post; n = 4 placebo, n = 12 letrozole) (C). o. It is usually used when you have been through a natural menopause. severe and sudden, unexplained troubled breathing. Thus, letrozole was expected to have a potential of improving luteal function and outcome in patients with advanced maternal age. • Letrozole (LET-roe-zole) is a drug that is used to treat breast cancer. Consideration should be given to monitoring BMD. hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or. Additionally, a study found that letrozole co-treatment could improve pregnancy outcomes by reversing the expression of anb3 integrin in the endometrium [ 40 ]. Letrozole lowers the levels of the female sex hormone oestrogen in the body. Letrozole was developed after Arimidex but before Aromasin, and it is the strongest and most potent of the three aromatase inhibitors by far. 5% of women randomised to letrozole had serious or fatal cardiac events compared with 1. Name of the medicinal product: Qualitative and quantitative composition: Therapeutic indications: Dosage (Posology) and method of administration. A manual pellet press was used to compress the triturate into 3. Not able to sleep. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median. 3 DOSAGE FORMS AND STRENGTHS. Include more protein and greens in your meals. The third-generation AI letrozole (Femara ®) was the result of this structure-activity approach to drug design and achieved the research goal of creating a highly potent and totally selective AI . : Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome. Letroz 2. Lezra tablet contains Letrozole | belongs to Non-steroidal aromatase inhibitor. The solution for oral inhalation is usually used. 3%) had hypoestrogenic. This is a decision. An RE could monitor you pre/post ovulation to check your follicles, hormones, etc to see if everything is working correctly. If estrogen is used, prescribe the lowest dose to relieve symptoms, monitor patient carefully and consider short term use. These compounds were also used to design pioneering molecular modeling techniques used to map the active site of aromatase [ 70 , 72 ]. 5-milligram tablets, and the dosing schedule will depend on its use. Shiatsu. A single-blind, crossover trial of 72 women whose HR+ breast cancer progressed on tamoxifen were randomized to either letrozole or anastrozole for four weeks and then crossed over to the other AI for another 4 weeks found significantly less reported joint pain in the letrozole arm than the anastrozole arm (3% vs 11%; p=0. Fertil Steril 2013;100:1740–4; Al-Fozan H, Al-Khadouri M, Tan SL, Tulandi T. 25 mg/kg BW of letrozole or a control every week for 2 months. Letrozole Bluefish belongs to a group of medicines called aromatase inhibitors. 35 for placebo and letrozole, respectively; P = . Alternate brands of Lezra tablet 2. 5 MG Tablet (30) online & get Flat 15% OFF on PharmEasy. 5 mg tablets in generic forms and under the brand name Femara. flushing (temporary warmth, redness. Letrozole. Adult: In hormone receptor +ve postmenopausal women: 2. Letrozole reduces the amount of estrogen by. Belly pain. The study design of SOLE—4 consecutive years with a 3-month letrozole treatment interruption and a final year of continuous letrozole use (year 5), following completion of 4–6 years of adjuvant anti-oestrogen (tamoxifen or an aromatase inhibitor) therapy, versus 5 years of continuous letrozole—is really a test of preplanned noncompliance rather than. increased cholesterol in your. 001). Letrozole is a generic drug also sold under the brand name Femara. Hair loss. Femar contains an active substance called letrozole. These breast cancers are called hormone sensitive or hormone receptor positive. In light of the accumulating clinical. It may also be used off-label for fertility issues. 71 and −3. Brand Name Price Savings;. We believe, in the light of the accumulating clinical research evidence, that letrozole is safe for use in assisted reproduction. Letrozole Tablets, USP are indicated for first-line treatment of postmenopausal women with hormone receptor positive or unknown, locally advanced or. Weight gain or loss. Letrozole is an oral medicine used to treat breast cancer in women who have already had their ovaries removed. The dosage usually lasts for 5 days to a week, if a tablet is taken every day. fast or pounding heartbeat. Tiredness and lack of energy may occur. This drug can also be used to prevent breast cancer from recurring. The procedure itself involves transferring semen that has been washed and concentrated directly into the uterus via a. It may also be used when someone is premenopausal and having treatment to stop the ovaries working (temporary menopause). Strengthen your Kegel muscles. S. 1 Recommended Dose - The recommended dose of letrozole tablets is one 2. Letrozole is an oral aromatase inhibitor which has been approved by the FDA 8. Eat a bigger breakfast and a smaller dinner. This drug has been available. Early-stage, hormone receptor–positive (HR+) breast cancer that has been treated. , 2015). It belongs to a group of medicines called aromatase inhibitors. Letrozole caused embryo-fetal toxicities in rats and rabbits at maternal exposures that were below the maximum recommended human dose (MHRD) on a mg/m 2 basis. Femara strength. Lez-T Letrozole 2. Instead, the Body Fat, using a Protein called Aromatase, produce it. Letrozole has an average rating of 5. While Letrozole is the preferred medication for PCOS based on. 5 mg once daily; continue until tumor progression. No dose adjustment is required for elderly patients. 1 mm diameter cylindrical pellets containing 60 mg of T and 4 mg of letrozole (60 mg T + 4 mg L). Letrozole can cost as little as $12 a month with a free letrozole coupon from SingleCare, versus the average monthly cash price of $321. A first- and second-line treatment for hormone receptor positive or unknown advanced breast cancer. Estrogen use with letrozole: use other options for conditions in which estrogen is indicated. Letrozole can induce ovulation in some of these women. It’s prescribed for adult females*. severe and sudden, unexplained troubled breathing. Letrozole may be mainly used to treat breast cancer patients. Hence, the likelihood of letrozole’s presence in the plasma at the time of embryo implantation is negligible. Lezra is used to treat postmenopausal breast cancer. 3 Use in Extended Adjuvant Treatment of Early Breast Cancer. Avoid alcohol as it may make you feel more tired and drowsy. Of the 23 boys recruited, 19 (9 on T + Lz, 10 on T + Pl) completed the initial 18-month follow-up. Letrozole is the most commonly used aromatase inhibitor for mild ovarian stimulation in ART (Requena et al. Common letrozole side effects include hot flashes, nausea, and fatigue. Letrozole is approved to be used alone or with other drugs to treat: Breast cancer in postmenopausal women who have any of the following types of breast cancer--. Nonmicronized T, letrozole, and stearic acid powders were mixed by mechanical means in a geometric ratio of 15:1:1. Still, there was a similar incidence between the letrozole and the control groups,. mild allergic reaction *†. 5 mg once daily for a planned duration of 5 years; discontinue at relapse.